Vol. 2 No. 1 (2019): Vol 2, Iss 1, Year 2019
Review Articles

Cytokines regulation and role in modulating cancer related pain

Anbreen Faisal
Department of Biochemistry and Biotechnology, Institute of life Sciences, University of Gujrat, Pakistan
Muhammad Asad Ullah
Department of Biotechnology, Quaid-i-Azam University 45320, Islamabad, Pakistan
Ayesha Bajwa
Department of Biochemistry and Biotechnology, Institute of life Sciences, University of Gujrat, Pakistan
Rizwan Nasir
Department of Biochemistry and Biotechnology, Institute of life Sciences, University of Gujrat, Pakistan
Muhammad Javed Iqbal
Department of Biotechnology, University of Gujrat, Sialkot Sub Campus, Pakistan
Muzamil Shah
Department of Biotechnology, Quaid-i-Azam University 45320, Islamabad, Pakistan
Wali Muhammad
Department of Biotechnology, Quaid-i-Azam University 45320, Islamabad, Pakistan
Published December 30, 2019
Keywords
  • Demodex mites, demodicosis, pathogenesis, literature review

Abstract

Cancer linked mechanism of inflammatory and neuropathic pain came out as complex pathologic process and a formidable clinical impasse. Over the decades significant headway has been made to unravel etiology of cancer pain and prime pathological maneuver tie with its microenvironment by models incited approaches. The cross talk between the cancer cell and their dynamic interaction decipher some of the cancer-induced inflammatory mediators which act in primary efferent neurons in absolute diversified way. Cytokines are the key inflammatory mediator in the microenvironment parole by cancerous cell and immune system cells that exert malicious autocrine and paracrine activity particular relevance to pain. To date very few strategies have been contemplated to modulate the release of cytokines that seems allied to cancer pain. In this scenario, the present review analyzes the main cytokines produced with peripheral and central mechanism analysis for better understanding their clinical traits. While treatment strategies are detailed with novel mechanistic insights that can have considerably cut down the pattern of neuropathic pain linked with tumorigenic estate.

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