Study of pancreas function for carbohydrate loading in diabetes with insulin resistance
- Morbus value (M value), Type 2 diabetes mellitus (T2DM), Calorie Restriction (CR), Homeostasis model assessment (HOMA), Insulinogenic Index (IGI), Area Under the Curve (AUC).
Background: Authors have continued clinical practice and research of Calorie Restriction (CR), Low Carbohydrate Diet (LCD) and Morbus (M) value for long.
Subjects and Methods: Subjects were 32 type 2 diabetes mellitus (T2DM) with more than 10 μU/mL of fasting immunoreacitve insulin (IRI). Methods included fundamental tests such as glucose, IRI, homeostasis model assessment (HOMA)-R, HOMA-β, and so on.
Results: Obtained data were as follows: average age 57.6 ± 12.8 years old, average HbA1c 7.6%. Median values are: average glucose 166 mg/dL, M value 46.6, fasting glucose 140 mg/dL, fasting IRI 12.4 μU/mL, HOMA-R 4.5, HOMA-β 60.3. M value showed significant correlation with HOMA-R and HOMA-β (p<0.01). M value showed significant correlations with HbA1c, average glucose, HOMA-R, HOMA-β (p<0.01). For the responses of glucose and IRI for 70g of carbohydrate, Delta Ratio of insulinogenic index (IGI) and Area Under the Curves (AUC) Ratio of IGI were studied. Significant correlation existed between HOMA-β and AUC Ratio of IGI (p<0.01).
Discussion and Conclusion: These results suggested the relationship among average glucose, HbA1c, M value, HOMA-R, HOMA-β, IGI, Delta and AUC Ratio of IGI, and so on. These findings would become fundamental and reference data for the future study in this field.